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Forskningsanslag
Professor Gwyn Gould
Insulin stimulates glucose transport into fat and muscle by promoting the movement of specialised transporter proteins from an internal storage depot to the cell surface. These transporter proteins function as specialised doorways through which glucose can move from the blood into fat and muscle for storage after a meal. By increasing the number of 'doorways' present in the boundary membrane of cells, insulin drives glucose into storage organs. This key action of insulin is known to be impaired in type 2 diabetes, resulting in insulin resistance and aberrant glucose homeostasis. This proposal is directed towards understanding how the distribution of these doorways is controlled within fat cells.
Källa:http://www.drwf.org.uk/Research/FundedResearch/tabid/358/ItemId/85/Default.aspx
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